SMart Nanoparticle-Hydrogel Hybrid System for Synergistic Eradication of Infection and Promotion of Wound Healing.

ABSTRACT: This study develops an efficient and intelligent photothermal therapy (PTT) system for treating Staphylococcus aureus-infected wounds by integrating a multifunctional hydrogel (PAOC-3@BA) with S. aureus-targeted photothermal nanoparticles (Fe₂O₃-CS@RBP). The Fe₂O₃-CS@RBP nanoparticles, functionalized with receptor-binding proteins (RBP) from bacteriophages, selectively recognize S. aureus and generate localized heat under near-infrared (NIR) irradiation for precise bacterial eradication. PAOC-3 hydrogel, loaded with the anti-inflammatory agent baicalin (BA), has a cloud point temperature (T_cp) of ≈47 °C and exhibits strong tissue adhesion and heat-induced contraction. Upon NIR-triggered heating, the hydrogel undergoes a turbidity trans

SUBMITTER: Wan H 

PROVIDER: S-EPMC12903975 | biostudies-literature | 2026 Feb

REPOSITORIES: biostudies-literature