Pre-Administration of Akkermansia Muciniphila Prevents the Development of Severe Acute Graft-Versus-Host Disease in Systemic Organs.

ABSTRACT: Acute graft-versus-host disease (aGvHD) remains a significant clinical challenge, with no optimal treatment despite advancements in medical science. This life-threatening condition, characterized by multi-organ involvement and high mortality, is increasingly linked to the gut microbiota. Therefore, this study investigates the protective effects of Akkermansia muciniphila on aGvHD, focusing on its capacity to modulate the gut microbiome and reduce disease symptoms. A. muciniphila is orally administered to mice prior to inducing aGvHD through allogeneic hematopoietic stem cell transplantation. The effects of A. muciniphila administration on the development of aGvHD are assessed through disease activity scoring, histological analysis, metabolite and immune profiling, and gut microbiota analys

SUBMITTER: Han JE 

PROVIDER: S-EPMC12903985 | biostudies-literature | 2026 Feb

REPOSITORIES: biostudies-literature