Boron Nitride Nanomaterials Trigger Immunomodulatory Effects in Human Broncho-Epithelial Cells by Modulating Eicosanoid Lipid Signaling.

ABSTRACT: For the successful commercial development of emerging 2D materials, it is crucial to understand their potential biological effects on healthy and diseased individuals. The present study demonstrates that a repeated low-dose (1 µg cm^-2 for 5 weeks) exposure of primary human broncho-epithelial (HBE) cell cultures to hexagonal boron nitride nanosheets (h-BN) and boron nitride nanotubes (BNNTs) increases the phospholipid, sphingolipid, and diglyceride content in cell membranes. Global lipidomics profiling further shows the induction of lipid mediator biosynthesis, especially after exposure to BNNTs in asthmatic cell cultures. The significant increase in leukotriene biosynthesis including its extracellular release is also confirmed in vivo in exposed mouse lungs. Mechanistically, ext

SUBMITTER: Gupta G 

PROVIDER: S-EPMC12904077 | biostudies-literature | 2026 Feb

REPOSITORIES: biostudies-literature