Stool-based SDC2/SFRP2/TFPI2 methylation assay for colorectal neoplasia screening: a multicenter, case-control study.

ABSTRACT:

Introduction

Colorectal neoplasia is a significant global health burden. Early detection is critical for improving clinical outcomes. However, developing a noninvasive strategy for routine detection of colorectal neoplasia remains challenging. This study evaluated the diagnostic performance of a combined SDC2/SFRP2/TFPI2 gene methylation stool DNA test for detecting colorectal cancer (CRC) and advanced adenoma (AA).

Methods

A multicenter, case-control study was conducted involving 409 patients with CRC, 82 patients with AA, and 495 control participants between July 2022 and March 2024. Stool samples were collected from all participants and analyzed for SDC2, SFRP2, and TFPI2 methylation using quantitative fluorescent polymerase chain reaction (PCR). To evaluate the detection

SUBMITTER: Li X 

PROVIDER: S-EPMC12904125 | biostudies-literature | 2026

REPOSITORIES: biostudies-literature