New Insights Into the Role of Polo-Like Kinase 3 in Lung Tumorigenesis.

ABSTRACT: Polo-like kinase 3 (PLK3) plays major roles in cell cycle regulation, DNA repair, and cellular responses to hypoxia. Our prior studies demonstrated that PLK3 negatively regulates the hypoxic response by directly phosphorylating and destabilizing HIF-1α and by destabilizing the E3 ubiquitin ligase SIAH2. We also find that PLK3 stabilizes PTEN by direct phosphorylation. Plk3 knockout mice exhibit increased spontaneous tumorigenesis in multiple organs, particularly the lung, at an advanced age. Tumors from these mice tend to be highly vascularized, consistent with the function of PLK3 in the hypoxic response. However, another study only observed increased tumorigenesis in female Plk3 knockout mice. The present study further explored the role of PLK3 in lung tumorigenesis. We find that PLK3 ca

SUBMITTER: Li C 

PROVIDER: S-EPMC12904140 | biostudies-literature | 2026 Feb

REPOSITORIES: biostudies-literature