High Risk of Colorectal Cancer After High-Grade Dysplasia in Inflammatory Bowel Disease Patients.

ABSTRACT:

Background

There are limited data on colorectal cancer (CRC) risk after high-grade dysplasia in inflammatory bowel disease.

Aims

To determine the long-term CRC and neoplasia risk after a first diagnosis of high-grade dysplasia in inflammatory bowel disease, and to assess utilisation of high-grade dysplasia treatment strategies over the past three decades.

Methods

In this nationwide retrospective cohort study, patients with colonic inflammatory bowel disease and high-grade dysplasia diagnosis between 1991 and 2021 were extracted from the Dutch nationwide pathology databank (PALGA). The primary outcome was the cumulative incidence of metachronous CRC. Kaplan-Meier curves were used to show proctocolectomy-free survival per decade.

Results

CRC was diagnosed in 348

SUBMITTER: Derks MEW 

PROVIDER: S-EPMC12904177 | biostudies-literature | 2026 Mar

REPOSITORIES: biostudies-literature