Differential protein expression profiles in human sperm from teratozoospermic and normozoospermic men identify LTBP1 and TGF-βR1 as potential biomarkers within the TGF-β signalling pathway.

ABSTRACT: Among cases of infertility, up to 50% are attributed to male infertility factors. Male infertility is associated with alterations in sperm proteins that are essential for normal sperm function. Alterations in proteins within the transforming growth factor-beta (TGF-β) signalling pathway are linked with several types of male infertility. However, the underlying mechanisms remain unclear. In this study, we proposed to use proteomic analysis to identify the proteomic profile in human sperm from normozoospermic (NOR) and teratozoospermic (TER) men. The results indicated 39 overlapping proteins associated with the TGF-β signalling pathway. Six proteins that were differentially expressed and had a log2 fold change of ≥ 1 or ≤ -1 were considered to be the differentially expressed proteins in huma

SUBMITTER: Kaewman P 

PROVIDER: S-EPMC12904376 | biostudies-literature | 2026

REPOSITORIES: biostudies-literature