Multi-epitope vaccine design against Monkeypox virus: An immunoinformatics approach.

ABSTRACT:

Background

The recent outbreak of the Monkeypox virus (MPXV) across multiple regions has highlighted the need for effective vaccine. This study employed an in-silico immunoinformatics approach to design a multi-epitope vaccine against monkeypox virus.

Methods

The IMV heparin binding surface protein (H3L) of MPV was selected as vaccine target. B and T cell epitopes were predicted and evaluated for their toxicity, allergenicity, antigenicity and global population coverage. A multi-epitope construct was assembled using adjuvant and appropriate linkers. The 3D vaccine structure was modelled, enhanced and then checked for its overall structure and physiochemical properties. The in-silico docking vaccine construct and TLR3 receptor was performed to check affinity and stability of

SUBMITTER: Ahmad S 

PROVIDER: S-EPMC12904572 | biostudies-literature | 2026

REPOSITORIES: biostudies-literature