Actigraphy-Quantified Physical Activity Measurements in Patients with Symptomatic <i>LMNA</i>-Related Dilated Cardiomyopathy in REALM-Dilated Cardiomyopathy.

ABSTRACT:

Introduction

Actigraphy-quantified physical activity (PA) allows for continuous measurements of PA that are reflective of real-world day-to-day functioning and morbidity in persons living with cardiomyopathy. This analysis reports the results of actigraphy monitoring and relates these to other clinical outcome assessments in the phase 3, multinational REALM-dilated cardiomyopathy (DCM) (NCT03439514) clinical trial in LMNA-related DCM.

Methods

Between 2020 and 2022, REALM-DCM randomized 37 patients with actigraphy worn on the nondominant wrist continuously to monitor daily PA. Of those, 35 participants had analyzable data for this analysis.

Results

The median duration of actigraphy monitoring for all participants was 293 days across 120 patient visits. Over 85%

SUBMITTER: Garcia-Pavia P 

PROVIDER: S-EPMC12904659 | biostudies-literature | 2026 Jan-Dec

REPOSITORIES: biostudies-literature