Integrated Use of Late Gadolinium Enhancement and Left Ventricular Global Longitudinal Strain in Hypertrophic Cardiomyopathy.

ABSTRACT:

Background

Late gadolinium enhancement (LGE) and left ventricular global longitudinal strain (LV-GLS) are structural and functional left ventricular remodeling markers in hypertrophic cardiomyopathy (HCM).

Objectives

This study investigated the prognostic value of integrating both markers for risk stratification in HCM.

Methods

Consecutive patients with HCM who underwent CMR between 2008 and 2020 at 2 tertiary hospitals were retrospectively analyzed. LGE% and LV-GLS were measured, with LV-GLS reported as an absolute value. The primary outcome was cardiovascular (CV) events: CV death, sudden cardiac death-related events, and heart failure hospitalization.

Results

Among 652 patients with HCM (median age 56 years; 74% [481 of 652] male), median LGE% and LV-GLS wer

SUBMITTER: Kwak S 

PROVIDER: S-EPMC12904828 | biostudies-literature | 2026 Feb

REPOSITORIES: biostudies-literature