DNAvi: integration, statistics, and visualization of cell-free DNA fragment traces.

ABSTRACT:

Summary

DNAvi is a Python-based tool for rapid grouped analysis and visualization of cell-free DNA fragment size profiles directly from electrophoresis data, overcoming the need for sequencing in basic fragmentomic screenings. It enables normalization, statistical comparison, and publication-ready plotting of multiple samples, supporting quality control and exploratory fragmentomics in clinical and research workflows.

Availability and implementation

DNAvi is implemented in Python and freely available on GitHub at https://github.com/anjahess/DNAvi under a GNU General Public License v3.0, along with source code, documentation, and examples. An archived version is available under https://doi.org/10.5281/zenodo.18401705.

SUBMITTER: Hess A 

PROVIDER: S-EPMC12904835 | biostudies-literature | 2026 Feb

REPOSITORIES: biostudies-literature