Impairment of the GABAergic system in the prefrontal cortex of male heroin addicts.

ABSTRACT: Opioid addiction is a global concern and the largest health burden among drug use disorders. Prefrontal cortex (PFC) regions play a key multifaceted role in behavioural regulation, and GABAergic interneurons regulate the output of the PFC, whose dysfunction has been linked to the behavioural abnormalities observed in opioid-addicted individuals. In these neurons, glutamate decarboxylase (GAD), with its isoforms GAD 65 and 67, is a key enzyme in the synthesis of GABA. Our study, which was performed on paraffin-embedded brains from the Magdeburg Brain Bank, aimed to investigate abnormalities in the GABAergic function of the PFC regions, i.e. the anterior cingulate cortex (ACC), the orbitofrontal cortex (OFC) and the dorsolateral prefrontal cortex (DLPFC), in opioid addiction by densitometric

SUBMITTER: von Gilsa A 

PROVIDER: S-EPMC12904868 | biostudies-literature | 2026 Feb

REPOSITORIES: biostudies-literature