Trajectories of lipid profile with cognitive function: 12-year follow-up of Guangzhou Biobank cohort study.

ABSTRACT: Studies on the trajectories of lipid profile with cognitive decline are scarce and inconsistent. We examined this association and explored potential effect modification. Lipid profiles including high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), triglycerides (TG) and total cholesterol (TC) were measured at baseline, first and second follow-ups, and classified into trajectory groups. Immediate, delayed memory recall and cognitive function were assessed by the immediate (IWRT) and delayed 10-word recall test (DWRT), and mini-mental state examination (MMSE), respectively, at baseline and follow-ups, and converted into standardized scores. Linear mixed-effect model was used. Results show that elevated HDL-C was associated with increasing annual change r

SUBMITTER: Tian YM 

PROVIDER: S-EPMC12904904 | biostudies-literature | 2026 Feb

REPOSITORIES: biostudies-literature