Relationships among peri-traumatic circulating endocannabinoids and long-term, negative outcomes following traumatic injury.

ABSTRACT:

Rationale

Traumatically injured individuals can develop chronic negative psychological sequelae. Improved understanding of contributing, peri-traumatic risk factors is essential to reduce the risk of these consequences. Previous studies have found that peri-traumatic, circulating endocannabinoid concentrations are positively associated with development of post-traumatic stress disorder (PTSD), chronic pain and depression months later, particularly in members of racial/ethnic groups that have been historically marginalized.

Objectives

This replication study examined relationships among peri-trauma serum endocannabinoid concentrations and long-term consequences in a cohort comprised primarily of individuals from marginalized racial and ethnic groups.

Methods

Participant

SUBMITTER: Albertina EA 

PROVIDER: S-EPMC12904968 | biostudies-literature | 2026 Feb

REPOSITORIES: biostudies-literature