Effects of acute alcohol administration on endocannabinoids and relation to subjective effects.

ABSTRACT:

Rationale

Harmful alcohol use remains a significant global public health challenge. Examining variability in the acute subjective effects of alcohol and related neurobiological mechanisms may advance the understanding of susceptibility to harmful alcohol use. Research suggests the endocannabinoid (eCB) system may play an important role in mediating the reinforcing effects of alcohol. This study examined the relationship between alcohol-induced changes in eCB concentrations and the subjective psychoactive effects of acute alcohol consumption.

Method

Healthy social drinkers (n = 28, aged 20-35 years) participated in a within-subjects, single-blind, placebo-controlled laboratory alcohol challenge study. Alcohol (0.6 g/kg; with 20% adjustment for women) and placebo sessions were

SUBMITTER: Petrie GN 

PROVIDER: S-EPMC12904980 | biostudies-literature | 2026 Feb

REPOSITORIES: biostudies-literature