Optimizing PET/CT protocols: is 60-minute [18 F]F-FDG uptake sufficient for cardiac sarcoidosis?

ABSTRACT:

Background

[¹⁸F]F-FDG PET/CT is an established imaging modality for diagnosing cardiac sarcoidosis (CS). While a 90-minute uptake time is commonly recommended to enhance target-to-background ratio, its added diagnostic value remains unclear. This study aimed to compare the diagnostic performance of 60-minute versus 90-minute uptake times. Eighty-seven patients (45 females, 42 males) with suspected CS underwent whole-body FDG PET/CT at 60 min post-injection (p.i.), followed by an additional chest scan at 90 min p.i. Patient preparation included a low-carbohydrate diet, prolonged fasting, and weight-based heparin administration. Three blinded readers with varying experience independently assessed the scans using binary classification for typical sarcoidosis-related FDG upt

SUBMITTER: Metzger G 

PROVIDER: S-EPMC12905051 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature