Elevated CHI3L1 and COX-2 levels correlate with menstrual pain severity in endometriosis.

ABSTRACT:

Objective

Endometriosis is a chronic gynecological disease associated with inflammation and severe pelvic pain in 6%-10% of women of reproductive age. Although the pathophysiology and management of endometriosis are currently understood, further research is needed to develop new diagnostic methods, particularly those involving inflammatory pathways, which could guide targeted therapies. This study aims to analyze the differences in levels of Chitinase-3-like protein 1 (CHI3L1) and Cyclooxygenase-2 (COX-2) in the walls of endometriosis cysts compared to non-endometriosis cysts (controls) and to evaluate the correlation of CHI3L1 with COX-2 and menstrual pain level using the Visual Analog Scale (VAS).

Methods

This observational analytical study utilized a cross-sectional desig

SUBMITTER: Rusly DK 

PROVIDER: S-EPMC12905068 | biostudies-literature | 2026

REPOSITORIES: biostudies-literature