Impact of relative dose intensity of first-line platinum-based chemotherapy in patients with thymic epithelial tumors: a retrospective study.

ABSTRACT:

Background

Platinum-based chemotherapy is the first-line treatment choice for advanced thymic epithelial tumors (TETs), with the expected objective response rate (ORR) ≈of 50% in thymoma and ≈20% in thymic carcinoma.

Objective

To evaluate the impact of relative dose intensity (RDI) on first-line treatment outcomes in TET patients.

Design

Retrospective cohort referred between 2016 and 2022 at the University of Naples Federico II, Italy.

Methods

Advanced TETs treated with first-line platinum chemotherapy; RDI calculated as delivered/planned dose intensity and categorized as low (<85%) or high (⩾85%). Outcomes: ORR, time to next treatment (TTNT), overall survival (OS).

Results

Thirty-three patients (15 thymoma, 18 carcinoma); 22 low RDI, 11 high RDI. RDI wa

SUBMITTER: Pietroluongo E 

PROVIDER: S-EPMC12905096 | biostudies-literature | 2026

REPOSITORIES: biostudies-literature