Disparities and trends in drug-related adverse reaction mortality in the United States, 1999-2020.

ABSTRACT:

Background

Adverse drug reactions (ADRs) are a leading cause of morbidity and mortality worldwide. Despite advances in pharmacovigilance, population-level evidence on long-term trends and disparities in ADR-related mortality in the United States remains limited.

Objectives

This study aimed to characterize national temporal trends and demographic, geographic, and drug-class disparities in ADR-related mortality.

Design

Population-based, cross-sectional analysis of US death certificate data using age-adjusted mortality rates (AAMRs) and log-linear estimated annual percentage changes (EAPCs) to assess temporal trends.

Methods

ADR-related deaths were identified using International Classification of Diseases, Tenth Revision (ICD-10) codes Y40-Y59. AAMRs and EAPCs wer

SUBMITTER: Guo L 

PROVIDER: S-EPMC12905101 | biostudies-literature | 2026

REPOSITORIES: biostudies-literature