Robust water-activated tissue adhesive patch for arterial/heart wound closure after intervention surgery.

ABSTRACT: Sealing of puncture points subsequent to interventional surgeries is a vital requirement for all interventional operations. Currently, large-diameter sheaths and transapical punctures present a significant challenge for wound closure, with a high probability of failure. In this study, we've developed a water-activated tissue adhesive patch (WAP) designed for quick and strong adhesion to blood vessel and heart tissue surfaces after surgery. This patch consists of a polyethylene glycol (PEG) derivative coating and a gelatin sponge. Upon contact with a vascular or cardiac wound, the PEG derivative coating quickly absorbs water, dissolves, undergoes rapid crosslinking, and adheres to the tissue surface. This patch can endure a burst pressure more than 300 mmHg and exhibits good biosafety, ther

SUBMITTER: Huang Y 

PROVIDER: S-EPMC12905230 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature