Distant recurrence and margin involvement in invasive breast cancer.

ABSTRACT: The effect of involved margins after breast cancer surgery on distant recurrence (DR) is unknown. We determined the association between margin width or involvement, DR and cancer deaths.

Patients and methods

Greater Manchester (GM) and the National Cancer Registry (NCRAS) cohorts were analysed. Margin status after curative surgery was measured. Cox-proportional hazards investigated factors associated with LR, DR and breast cancer deaths.

Results

In GM (2010-2014), 2295 (70.2%) patients had clear margins ( > 2 mm), 302 (9.2%) close (1-2 mm) and 673 (20.6%) involved ( < 1 mm) margins. 2030 patients underwent breast conservation surgery (BCS). After multivariable adjustment in BCS patients, involved margins had an increased hazard of DR (HR 1.73, 95% CI:1.03, 2.88, p = 0.037) an

SUBMITTER: Michael S 

PROVIDER: S-EPMC12905278 | biostudies-literature | 2026 Mar

REPOSITORIES: biostudies-literature