Resting-state brain function and its modulation by intranasal oxytocin in antisocial personality disorder with and without psychopathy.

ABSTRACT: Behavioural, structural, and functional neuroimaging differences exist between individuals with antisocial personality disorder with (ASPD + P) or without psychopathy (ASPD-P). However, the aetiological mechanisms underpinning such differences remain unclear, hindering treatment development. Intranasal oxytocin (OT) has shown modulatory effects on social brain function in healthy and antisocial populations. We investigated the effects of OT on resting-state brain function in individuals with violent offending histories with ASPD+/-P using arterial spin labelling to measure regional cerebral blood flow (rCBF). A double-blind, placebo-controlled, crossover design was employed with males with ASPD (ASPD + P: N = 17, ASPD-P: N = 14) and healthy male non-offenders (N = 22). Both ASPD subtypes e

SUBMITTER: Griem J 

PROVIDER: S-EPMC12905299 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature