Comparative prognostic value of high-sensitivity cardiac troponin T and NT-proBNP for 30-day mortality in non-cardiac critically ill patients.

ABSTRACT: High-sensitivity cardiac troponin T (hs-cTnT) and N-terminal pro-B-type natriuretic peptide (NT-proBNP) are organ-specific biomarkers reflecting myocardial injury and cardiac biomechanical stress, respectively. Yet, neither is disease-specific, and both are frequently elevated in critically ill patients even in the absence of acute cardiac disease. This lack of specificity complicates their interpretation, and their relative prognostic importance remains uncertain. We retrospectively analyzed 827 adults admitted to ICU, excluding acute cardiac admissions and compared the prognostic utility of hs-cTnT and NT-proBNP measured at ICU admission for predicting 30-day mortality in non-cardiac critically ill patients. Non-survivors had higher hs-cTnT (67.2 vs. 37.7 ng/L; p < 0.001) and NT-proBNP (

SUBMITTER: Swistek R 

PROVIDER: S-EPMC12905346 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature