DANEELpath open source digital analysis tools for histopathological research in neuroblastoma models.

ABSTRACT: Despite the considerable expansion of bioimage analysis as a subfield of biomedical sciences, there is an ongoing need for comprehensive image analysis pipelines to address specific biological inquiries. In the tumor microenvironment, the extracellular matrix (ECM) plays a pivotal role in cancer progression, promoting tumor cell adaptability, intratumor heterogeneity, and therapeutic resistance. In neuroblastoma (NB), the ECM glycoprotein vitronectin (VN) has been associated with more aggressive tumors. Three-dimensional (3D) hydrogels are an emerging biomimetic tool with significant potential for studying the role of ECM elements and testing new mechano-drugs such as cilengitide, a potential therapeutic agent to treat high-risk NB due to its ability to inhibit VN activity in cells. To gai

SUBMITTER: Vieco-Marti I 

PROVIDER: S-EPMC12905389 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature