Injectable hydrogels for osteomyelitis treatment induce metabolic reprogramming for protection against reinfection.

ABSTRACT: Osteomyelitis, especially multidrug-resistant cases, remains a formidable clinical challenge due to recurrent infections and antibiotic limitations. Here, we present an injectable GaCu_Van&HA_CHO-BSA hydrogel that self-assembles in situ within the bone marrow cavity-the epicenter of trained immunity-to simultaneously eradicate pathogens, induce innate immune memory, and regenerate bone. The hydrogel captured bacteria, virulence factors, and inflammatory mediators through multivalent interactions with enhanced injectability, biocompatibility, and sustained antigen release, making it ideal for minimally invasive treatment of osteomyelitis-related bone defects. Mechanistically, adsorbed pathogen signatures activated pattern recognition receptors, triggering metabolic repro

SUBMITTER: Chen H 

PROVIDER: S-EPMC12905414 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature