Dietary eggshell membrane modulates gut microbiota and alleviates AOM/DSS-induced colonic inflammation in mice.

ABSTRACT: Persistent intestinal inflammation and gut dysbiosis are key drivers of the progression from inflammatory bowel disease (IBD) to colitis-associated colorectal cancer (CAC). Eggshell membrane (ESM) has shown beneficial effects in alleviating IBD symptoms; however, its impact on inflammation-driven CAC remains unclear. This study investigated the effects of dietary ESM supplementation in an azoxymethane/dextran sulfate sodium (AOM/DSS)-induced CAC mouse model. Mice were fed either a control or ESM-supplemented diet for one month prior to CAC induction and continuing throughout the experiment. ESM supplementation significantly improved survival rates in AOM/DSS-induced CAC mice and reduced colitis severity, indicated by the down-regulation of the pro-inflammatory cytokines and M1-like macroph

SUBMITTER: Yin W 

PROVIDER: S-EPMC12905501 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature