A single biomarker may not yield a reliable binary clinical answer: B cell lymphoma 6 testing and resulting interventions for endometriosis in infertility care.

ABSTRACT:

Objective

To study the associations of B cell lymphoma 6 (BCL6) in endometrial endometriosis, and to determine a practice's experience testing BCL6 in patients with recurrent pregnancy loss/recurrent implantation failure (RPL/RIF).

Design

Retrospective chart review.

Subjects

Endometrial samples were collected at the time of laparoscopy from 19 reproductive-aged individuals with known stage II-IV endometriosis. Endometrium biopsies were also collected from eight healthy controls, at a single academic center.

Exposure

Results using standard immunohistochemical staining for BCL6 on endometrial biopsies from October 2019 to March 2023 were obtained. For the in vitro fertilization patients with a positive BCL6 result (HSCORE≥1.4), postbiopsy interventions on

SUBMITTER: Taggar A 

PROVIDER: S-EPMC12905616 | biostudies-literature | 2026 Feb

REPOSITORIES: biostudies-literature