Cross-binding antibodies capable of neutralising diverse hantaviruses are produced in response to Puumala virus infection.

ABSTRACT:

Background

Orthohantaviruses (hantaviruses) are emerging rodent-borne pathogens that can cause severe human disease. They are present on multiple continents and are responsible for thousands of human cases per year. Despite this, no licenced therapeutics are available, vaccines for most strains are lacking, and the immunological response to infection is poorly characterised. This study aimed to analyse the humoral immune response to Puumala virus (PUUV) infection to inform future studies focussing on the production of therapeutic monoclonal antibodies and vaccination strategies.

Methods

Serum was obtained from a cohort of 24 patients hospitalised with PUUV infection at four time points, covering the early acute, late acute, early convalescent, and late convalescent stages of

SUBMITTER: Clark JJ 

PROVIDER: S-EPMC12905621 | biostudies-literature | 2026 Feb

REPOSITORIES: biostudies-literature