Spatial signature of low-frequency network changes accounts for pallidal stimulation outcome in cervical dystonia.

ABSTRACT:

Background

Pallidal deep brain stimulation (DBS) has remarkable effects in patients with cervical dystonia. Yet, its neurophysiological mechanisms are not fully resolved to date. Converging evidence suggests that pallidal DBS modulates sensorimotor and cerebellar network activity in dystonia, possibly by disrupting pathologically enhanced low-frequency oscillations in the basal ganglia. Still, anatomical and electrophysiological findings have rarely been linked, and it is unclear whether oscillatory changes occur in the same network identified in neuroimaging studies.

Methods

In this cross-sectional study, we investigate the effects of pallidal DBS in patients with cervical dystonia using magnetoencephalography recordings on and off stimulation. We correlated DBS outcomes to

SUBMITTER: Bahners BH 

PROVIDER: S-EPMC12905622 | biostudies-literature | 2026 Feb

REPOSITORIES: biostudies-literature