Association between body mass index and risk of breast cancer according to breast cancer subtypes: A systematic review and meta-analysis.

ABSTRACT:

Background

Higher body mass index (BMI) is a risk factor for breast cancer (BC) development, but the relationship with BC subtypes in pre- and post-menopausal women remains unclear.

Methods

We performed a systematic search from PubMed, Embase and Cochrane databases until 09/24 (CRD42020206108) for cohort and case-control studies assessing the association between BMI and BC subtypes and/or menopausal status. BC risk in overweight (BMI 25-29.9 kg/m²) or obese (BMI≥30 kg/m²) subjects was compared to risk in under/normal weight (BMI<25 kg/m²). BC subtypes were classified as i) ER-positive (regardless HER2-status) ii) ER-negative (regardless HER2-status) iii) HER2-positive (regardless ER-status); iv) triple-negative BC (TNBC).

Results

Out o

SUBMITTER: Dauccia C 

PROVIDER: S-EPMC12905738 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature