Breast cancer risk in women with neurofibromatosis type 1: a register-based cohort study from Denmark and Sweden.

ABSTRACT:

Background

An increased risk of breast cancer has been reported in women with neurofibromatosis type 1 (NF1), especially at younger ages, and NF1-related breast cancer has been associated with poor survival. We performed a large population-based cohort study to estimate the age-related breast cancer risk and survival in Danish and Swedish women with NF1.

Patients and methods

We used national registers to identify all women with a diagnosis of NF1 in Denmark and Sweden born between 1930 and 1990 (Denmark) or 1987 (Sweden). Age- and sex-matched comparisons were randomly selected from population registers. Cox proportional hazards models were used to study the association between NF1, breast cancer risk, and overall 5-year mortality after a breast cancer diagnosis.

Results</

SUBMITTER: Tettamanti G 

PROVIDER: S-EPMC12905740 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature