Injured cardiac targeting magnetic nanovesicles for mRNA treatment of myocardial infarction.

ABSTRACT: Rationale: Inflammation and myocardial remodeling are major contributors to the progression of cardiac diseases. mRNA-based therapeutics have emerged as a promising modality for cardiovascular intervention; however, their clinical translation remains constrained by challenges in achieving efficient and spatially precise delivery to diseased cardiac tissue, particularly following myocardial injury. To address this unmet need, a dual-active magnetic nanocarrier was engineered for targeted mRNA delivery to damaged cardiovascular tissue. Methods: The interleukin-10 anti-inflammatory cytokine mRNA (IL-10 mRNA) was encapsulated in lipid nanoparticles, which were fused with nanovesicles derived from mesenchymal stem cells (NVs) and functionalized with cardiac-targeting peptid

SUBMITTER: Mun D 

PROVIDER: S-EPMC12905742 | biostudies-literature | 2026

REPOSITORIES: biostudies-literature