Smart nebulized ROS-responsive hydrogel microspheres loaded with UC-MSCs-derived exosomes for the treatment of acute lung injury.

ABSTRACT: Acute Lung Injury (ALI) and Acute Respiratory Distress Syndrome (ARDS) are rapidly progressing, highly fatal clinical syndromes characterized by acute and progressive hypoxic respiratory failure. These conditions result in significant morbidity and mortality, yet no specific treatments are currently available, with management relying largely on symptomatic and supportive care. The pathogenesis of ALI/ARDS is closely linked to the excessive production of reactive oxygen species (ROS) and an uncontrolled inflammatory response, which collectively drive disease progression and tissue damage. To address this, we have developed a novel ROS-responsive hydrogel microsphere encapsulating human umbilical mesenchymal stem cell-derived exosomes, designated Exo@TK@CaAlg hydrogel microspheres. The desig

SUBMITTER: Liu C 

PROVIDER: S-EPMC12905755 | biostudies-literature | 2026 Apr

REPOSITORIES: biostudies-literature