Long Noncoding RNA SATB1-AS1 Suppresses Inflammatory Response and Injury in Dental Pulp Stem Cells Through the miR-15a-5p/E2F3 Axis.

ABSTRACT:

Introduction and aims

Pulpitis represents a prevalent dental condition where inflammatory tissue damage can advance into irreversible stages or pulp death, ultimately compromising oral health-related quality of life. This study investigated the role and underlying mechanisms of long noncoding RNA SATB1-AS1 in pulpitis progression, offering potential therapeutic targets for this condition.

Methods

This study included 50 patients with irreversible pulpitis (pulpitis group) and 50 age- and gender-matched orthodontic extraction controls (control group). The expression of SATB1-AS1 in pulpitis tissues was assayed using real-time quantitative PCR. A pulpitis model was established by treating human dental pulp stem cells (DPSCs) with lipopolysaccharide (LPS). Evaluation of DPSC pro

SUBMITTER: Ding S 

PROVIDER: S-EPMC12905757 | biostudies-literature | 2026 Feb

REPOSITORIES: biostudies-literature