Non-invasive identification of brain signatures of acute liver injury.

ABSTRACT: Background: In many disorders, metabolic and inflammatory derangements that originate in peripheral organs have a deleterious impact on the brain. Brain functional impairment, defined as hepatic encephalopathy, is one of the main diagnostic criteria for acute liver failure (ALF), a severe complication of acute liver injury (ALI). While brain inflammation (neuroinflammation) and metabolic alterations significantly contribute to hepatic encephalopathy, their non-invasive evaluation remains challenging. Methods: To address this limitation, we utilized dual radiotracer [¹⁸F]-fluoro-2-deoxy-2-D-glucose ([¹⁸F]FDG) and [¹¹C]-peripheral benzodiazepine receptor ([¹¹C]PBR28) microPET imaging followed by conjunction analysis and metabol

SUBMITTER: Palandira SP 

PROVIDER: S-EPMC12905780 | biostudies-literature | 2026

REPOSITORIES: biostudies-literature