Targeting multidrug-resistant <i>Candida</i>: Cu_xTe nanoflowers synergistically facilitate fungal clearance via cuproptosis death and host immune activation.

ABSTRACT: Candida species are common infectious pathogens that can cause invasive infections with potentially life-threatening consequences. Current treatments for invasive Candida infections are primarily azoles and echinocandins. However, emerging antifungal drug resistance compromises therapeutic efficacy. Herein, a stable Cu_xTe nanoflower was designed to combat fungal infections via cuproptosis death and immune activation. Firstly, Cu and Te precursors were added to an auxiliary reducing agent and solvent, and Cu_xTe nanoflowers with a multibranched dendritic structure were synthesized via a temperature-controlled solution-phase method. Cu_xTe nanoflowers effectively inhibit fungal growth, damage fungal cell membranes and walls, and show significant f

SUBMITTER: He Y 

PROVIDER: S-EPMC12905793 | biostudies-literature | 2026 Apr

REPOSITORIES: biostudies-literature