Pulmonary Hemodynamics and Long-Term Outcomes in Children with Pulmonary Hypertension-Associated Bronchopulmonary Dysplasia.

ABSTRACT:

Objective

To determine whether the severity of pulmonary hypertension (PH), assessed at cardiac catheterization, is associated with bronchopulmonary dysplasia (BPD) severity and mortality.

Study design

We analyzed clinical data from subjects with BPD-PH enrolled in the PPHNet Registry between 2014 and 2024. BPD severity was based on the Neonatal Research Network grading system at 36 weeks postmenstrual age. Survival and clinical associations were estimated using Cox proportional hazards regression with delayed entry-to-risk-set and competing risk methodologies.

Results

The study included 320 subjects (gestational age, 25.8 ± 2.0 weeks (range 22.2 to 31.6 weeks); postnatal age 5.0 months (IQR 3.3, 8.6; range birth to 12 years) at the time of PH diagnosis. The severity

SUBMITTER: Austin ED 

PROVIDER: S-EPMC12905831 | biostudies-literature | 2026 Feb

REPOSITORIES: biostudies-literature