Brain and circulating EV proteome signatures in schizophrenia as prognostic markers for age-related dementia.

ABSTRACT: Schizophrenia (SZ) is epidemiologically linked to an increased risk of developing age-related dementias (ARD) predominantly characterized by Alzheimer's disease and vascular dementia. However, the molecular mechanisms underlying this association remain insufficiently elucidated. Extracellular vesicles (EVs) play a critical role in neuropathological processes and offer a promising avenue for identifying shared disease mechanisms and potential circulating markers for patient stratification. Here we used a two-phase systems biology approach integrating discovery-driven proteomics with a targeted validation strategy using data-independent acquisition mass spectrometry (DIA-MS) in a large, independent SZ cohort. First, we analyzed brain-derived EVs (bEVs) from post-mortem SZ and ARD subjects to

SUBMITTER: Sanchez Milan JA 

PROVIDER: S-EPMC12905883 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature