Synergistic apoptosis induction in myelodysplastic syndrome cells by azacitidine and PIM-2 inhibitors via nuclear factor-kappa B pathway inhibition.

ABSTRACT:

Background

We aimed to characterise the molecular effects of treating myelodysplastic syndrome (MDS) cells with the DNA methyltransferase inhibitor azacitidine and an PIM-2 inhibitor, focusing on their potential synergistic effects.

Methods

MDS cells were subjected to proliferation assays to assess the effects of each drug independently and in combination. The synergy of the drugs in promoting the apoptosis of MDS cells via NF-κB signalling pathway inhibition was evaluated.

Results

Our results suggested that azacitidine and the PIM-2 inhibitor have synergistic effects in inhibiting the proliferation and inducing the apoptosis of MDS cells. Furthermore, the combined application of azacitidine and PIM-2 inhibitor synergistically inhibited the NF-κB pathway, resulting in

SUBMITTER: Guo Y 

PROVIDER: S-EPMC12905915 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature