Marine n-3 fatty acid treatment for carotid plaques in patients with type 2 diabetes.

ABSTRACT:

Background

Carotid plaques result from a blockage or narrowing of carotid arteries associated with severe atherosclerotic cardiovascular diseases. We aimed to assess the effect of marine n-3 fatty acid supplementation on carotid plaques among patients with diabetes and whether the effect was modified by genetics.

Methods

In this 14 month double-blind, randomized controlled trial, 415 patients with type 2 diabetes (T2D) were randomly assigned to receive high-dose (3.0 g/day) or low-dose (1.5 g/day) marine n-3 fatty acids (fish oil) or placebo (refined olive oil). The primary outcome was the prevalence of carotid plaques. Secondary outcomes included changes in NMR-derived lipoprotein subclasses. Genetic interactions with the supplementation were also explored.

Results

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SUBMITTER: Zhuang P 

PROVIDER: S-EPMC12905938 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature