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Prospective open-label trial of personalised connectivity-guided transcranial magnetic stimulation therapy for migraine.


ABSTRACT:

SUBMITTER: Zhen Z 

PROVIDER: S-EPMC12905967 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature

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Prospective open-label trial of personalised connectivity-guided transcranial magnetic stimulation therapy for migraine.

Zhen Zhen Z   Li Yunze Y   Zhou Jie J   Li Han H   Zalesky Andrew A   Cash Robin R   Feng Zhiying Z   Che Xianwei X  

The journal of headache and pain 20260121 1


BACKGROUND: Migraine is a leading cause of disability worldwide, affecting hundreds of millions of individuals. Repetitive transcranial magnetic stimulation (rTMS) offers a non-invasive therapeutic option, yet long-term effects remain unclear. We investigated whether rTMS treatment effects could be extended by personalising stimulation targets based on connectivity between the pregenual cingulate cortex (PGC) and dorsolateral prefrontal cortex (DLPFC)-a neural pathway implicated in migraine path  ...[more]

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