Neutrophil-derived exosomes inhibit gastric cancer progression via miR-101-3p-mediated suppression of MCL1.

ABSTRACT:

Background

Neutrophils, serving as crucial innate immune cells, exert anti-tumor effects through cytotoxic mediators, antibody-dependent responses, and coordination of immune networks. They also release exosomes that carry bioactive molecules such as microRNAs (miRNAs). Our previous work identified neutrophil-derived exosomes (N-Exo) as contributors to their anti-tumor activity, but the underlying mechanisms remain unclear.

Methods

Functional experiments integrating high-throughput sequencing and validation assays were performed to screen and identify key anti-tumor miRNAs in N-Exo. An in vivo subcutaneous xenograft mouse tumor model assessed the therapeutic effects of N-Exo-delivered miR-101-3p on tumor growth. Bioinformatics analysis combined with experimental validation,

SUBMITTER: Wang J 

PROVIDER: S-EPMC12906046 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature