Environmental ciprofloxacin triggers pregnancy loss: senescence-driven miscarriage via TRIM21-mediated MFF degradation.

ABSTRACT:

Background

Antibiotic abuse has become a top public health problem worldwide. Ciprofloxacin (CIP) has the highest detection rate in human but its association with unexplained miscarriage (UM) is completely unknown. Senescence is a ubiquitous cellular process but its association with UM is still unclear.

Methods

We combined case-control study using a UM case-control group and in vitro functional assays using mouse model and human trophoblast HTR-8/SVneo cells. The associations between environmental exposure to CIP and cell senescence were explored. Trophoblast cell senescence, the mitochondrial dysfunctions, and the TRIM21-mediated ubiquitination degradation of MFF were investigated.

Findings

Higher urinary CIP levels are associated with villous tissue senescence and w

SUBMITTER: Sun 孙义 Y 

PROVIDER: S-EPMC12906125 | biostudies-literature | 2026 Feb

REPOSITORIES: biostudies-literature