MUC20 alleviates kidney fibrosis by modulating pyroptosis through the MET/RAS/STING axis.

ABSTRACT: Rationale: Mucins are epithelial transmembrane glycoproteins involved in inflammation and kidney dysfunction, yet the role of the transmembrane mucin MUC20 in renal injury and fibrosis remains unclear. This study aimed to define the functional significance and underlying mechanisms of MUC20 in kidney fibrosis. Methods: Muc20-deficient mice and tubular epithelial cell models were used to evaluate renal fibrosis and pyroptosis in induced kidney injury. Molecular and biochemical approaches were applied to assess protein interactions, RAS activation, 2'3'-cGAMP production, cGAS-STING signaling, lysosomal integrity, potassium efflux, and NLRP3 inflammasome activation. Results: Loss of MUC20 significantly exacerbated renal fibrosis and increased pyroptosis in tubular

SUBMITTER: Huang J 

PROVIDER: S-EPMC12906183 | biostudies-literature | 2026

REPOSITORIES: biostudies-literature