Multimorbidity phenotypes and associated characteristics in severe asthma: an observational study of European severe asthma registries.

ABSTRACT:

Background

The phenotypic nature of multimorbidity in severe asthma is poorly understood. Our aims in this study were to define multimorbidity phenotypes and their characteristics in severe asthma across Europe by identifying and characterising co-aggregation of comorbidities.

Methods

Cross-sectional patient data were analysed from the pan-European Severe Heterogenous Asthma Research Collaboration: Patient Centred (SHARP) Central database of national severe asthma registries. Patients were grouped by four European regions (North, South, East, and West). Hierarchical clustering of comorbidities was applied to characterise the correlation structure of the ten commonest comorbidities within these geographical regions. Subsequent multimorbidity phenotypes (MMP) and their clinica

SUBMITTER: Freeman A 

PROVIDER: S-EPMC12906202 | biostudies-literature | 2026 Apr

REPOSITORIES: biostudies-literature