A Novel Functional Ingredient Derived From a Mixture of Mulberry (<i>Morus alba</i> L.) Leaves and Butterfly Pea (<i>Clitoria ternatea</i> L.) Flowers Enhances Rapid Eye Movement Sleep, Cognitive Function, and Anxiolytic Behavior via GABA_A Receptor-Dependent Mechanism in Rats.

ABSTRACT: The neuropharmacological benefits for sleep quality and mental health from the extracts of Morus alba L. leaves (MA) and Clitoria ternatea L. flowers (CT) have been revealed previously. However, due to synergistic interactions of polyherbal ingredients, the positive effects of MA mixed with CT are still controversial. Preliminary outcomes from in vitro assessment exposed that a 3:1 ratio of MA:CT (MACT) yielded the highest antioxidant capacity and gamma-aminobutyric acid (GABA)-promoting activity among seven combination ratios: 0MA:1CT, 1MA:0CT, 1MA:1CT, 1MA:2CT, 1MA:3CT, 2MA:1CT, and 3MA:1CT. Male Wistar rats (n = 6/group) were electroencephalographically and electromyographically monitored to confirm the sedative-hypnotic function of the assigned ingredients over 3 h

SUBMITTER: Nukitram J 

PROVIDER: S-EPMC12906349 | biostudies-literature | 2026

REPOSITORIES: biostudies-literature