Spatial abilities in aging adults with Down syndrome.

ABSTRACT:

Introduction

People with Down syndrome (DS) have a higher likelihood of developing Alzheimer's disease (AD). Deficits in spatial abilities could serve as early indicators of AD. We examined age effects on visuospatial construction and visuomotor integration in DS and whether spatial tasks could distinguish various extents of cognitive decline in DS.

Methods

We used the Alzheimer's Biomarkers Consortium-Down Syndrome project dataset, where 376 DS participants completed a series of cognitive measures.

Results

Age effects were found in visuomotor integration but not in visuospatial construction. Both abilities declined with AD progression. While both abilities showed relatively poor discrimination between cognitively stable (CS) and mild cognitive impairment (MCI) and be

SUBMITTER: Yang Y 

PROVIDER: S-EPMC12906371 | biostudies-literature | 2026 Feb

REPOSITORIES: biostudies-literature