SynDNA vaccine against TCR chains and neoantigens for T cell lymphoma therapy.

ABSTRACT: T cell lymphomas constitute approximately 10% of all non-Hodgkin lymphomas and are associated with poor prognosis. Patients experiencing early relapse post-treatment exhibit a 5-year overall survival rate of 11%, underscoring the need for improved therapeutic strategies. The clonality of T cell cancers makes the T cell receptor (TCR) an appealing target for immunotherapy. Here, we developed and evaluated a synDNA vaccine against the TCR⍺, β, and γ chains (TCRfullvax) of the EL4 murine T cell lymphoma model. Immunogenicity studies revealed induction of robust T cell responses against all three TCR chains, with identification of immunodominant epitopes for each chain. Notably, we observed no significant differences in the number of live T cells between TCRfullvax-vaccinated group and control

SUBMITTER: Bhojnagarwala PS 

PROVIDER: S-EPMC12906415 | biostudies-literature | 2026 Feb

REPOSITORIES: biostudies-literature