Unveiling the molecular impact of pulmonary embolism on the right ventricle: a multi-layer transcriptomic study in a porcine model.

ABSTRACT: Venous thromboembolism (VTE) is a prevalent and potentially fatal condition, typically initiating deep vein thrombosis (DVT). Subsequent embolization can lead to pulmonary embolism (PE), a significant threat to cardiovascular function. Approximately 5% of PE cases result in sudden cardiac arrest due to acute right ventricular failure, arrhythmias, and circulatory shock. Given the considerable influence of PE on right ventricular function, this study aimed to investigate alterations in gene expression within the right ventricle associated with PE in a porcine model. The study was performed on 12 male pigs, divided into two groups of six animals each. In the experimental group, a thrombus was induced in the right femoral vein of each animal and subsequently released to induce pulmonary embol

SUBMITTER: Gromadzinski L 

PROVIDER: S-EPMC12906535 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature