Pan-cancer multi-omics profiling of OAS3 reveals its immunological and prognostic associations across human cancers.

ABSTRACT:

Background

The enzyme 2'-5'-oligoadenylate synthetase 3 (OAS3) plays a well-established role in antiviral immunity, but its involvement in cancer biology remains poorly understood. This study aimed to comprehensively investigate the expression patterns, mutation characteristics, prognostic significance, functional roles, and therapeutic potential of OAS3 across multiple cancer types.

Methods

Utilizing multi-omics data from public cancer databases, we analyzed OAS3 expression patterns, survival correlations, immune interactions, pathway enrichment, genomic associations, mutation profiles, and functional validation of OAS3 knockdown in THP-1 cells for apoptosis assays.

Results

OAS3 expression was significantly upregulated in 32 cancer types, highlighting its context-dep

SUBMITTER: Zhang X 

PROVIDER: S-EPMC12906706 | biostudies-literature | 2026

REPOSITORIES: biostudies-literature